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In the world, more and more people are suffering from the inability of their immune systems to distinguish between healthy cells and invading microscopic organisms. Their organs and tissue are now being attacked by the disease defenses which they had previously.




Major international research efforts are being made to combat this trend - such as an initiative in London's Francis Crick Institute, where two world-renowned experts, James Lee and Carola Vinuesa, have set up separate research groups to help pinpoint the precise reasons behind autoimmune diseases and other conditions. known.


Lee stated to the Observer, that autoimmune cases increased in the west around 40 years back. New cases are being reported in countries where these conditions have never been seen before.


For instance it is the Middle East and East Asia are the regions that have the highest number of cases of inflammatory intestinal disease. Before that they had hardly seen the disease.


Type 1 diabetes is among the autoimmune disorders. Other conditions include rheumatoid disease, inflammatory bowel and multiple sclerosis. In all cases your immune system gets confused and switches to healthy tissue over infectious agents.


The UK has at most 4 million individuals suffering from these ailments. There are also numerous other. Globally, it's estimated that the incidence of autoimmune diseases is rising at a rate of between 3%-9% per annum. Many scientists believe environmental factors are the primary factor in this rise.


Lee who used to be located in Cambridge University, stated that human genetics have not changed in the last couple of years. So, something is happening within our bodies that can increase our risk of developing an autoimmune disease.


This idea was backed by Vinuesa who was based at the Australian National University. She mentioned the shifts in food habits that took place when more nations adopted west-style diets and people were eating more fast food.


Vinuesa stated that fast-food meals contain a few essential ingredients, like fiber. Evidence suggests that this change could affect a person's microbiome which is the accumulation of microorganisms living in our gut. Microorganisms play a important role in controlling a variety of bodily functions.


These changes to our microbiomes can trigger autoimmune disorders that are of over 100 different types.


The two scientists emphasized the fact that each person is susceptible to the diseases. It includes celiac, as well as Lupus. It triggers inflammation, swelling, and can cause damage and death to many organs, including heart.


Vinuesa clarified that autoimmune diseases aren't something you can develop if you don't have a specific genetic susceptibility. We can't stop the spread of fast-food Check out chains around the world. Instead, we're trying to understand how autoimmune diseases can be caused and what genetic causes make certain people more susceptible to autoimmune diseases than others. That is the level at which we intend to address this issue."


Scientists now have the ability to identify tiny differences in DNA between large numbers of individuals. This is made possible by the use of the development of new methods. It is possible to identify common genetic patterns among individuals suffering from an autoimmune condition.


Lee states that even though we had the tools to sequence DNA the point of being able to sequence DNA, until recent but it was not feasible. My research revealed that there are about six DNA variants involved in the development of inflammatory bowel diseases. Today, we have more than 250.


This is the heart of Lee's and Vinuesa’s work. They are trying to understand the different ways that genetic pathways work and uncover the various kinds of diseases that doctors are currently studying. Vinuesa explained that there may be multiple versions of certain autoimmune disorders, like Lupus. It is essential to realize that this can have consequences in determining the right treatment.


There are numerous treatments being developed but we don’t know which patients to give them. We don't know what type of disease the patient has. This is an important goal in research into autoimmune diseases. It is crucial to know how to classify and categorize patients in order to give them the appropriate treatment.


Lee said that with the rise in autoimmune diseases across the globe, new treatments and medications are needed more urgently than ever. Lee said there was at present no treatment for autoimmune disorders. These tend to develop in young people trying to complete their studies, get a job, and start families.


This means that a growing amount of people need surgery or require regular injections throughout their entire life. This can be a nightmare for patients as well as a significant burden on health care services. Therefore, it is imperative to discover effective and innovative treatment options.


Rheumatoid arthritis is an auto-immune disorder. It is a condition where the immune system is attacking healthy tissues. It's not clear what causes this.


Your immune system produces antibodies that fight viruses and bacteria, which helps to fight off infections.


If you suffer from Rheumatoid arthritis, your immune systems mistakenly transmits antibodies to your joints' lining, where they target the tissues around them.


The thin layer of cells (synovium) covering the joints to become sore and inflamed. It releases chemicals that harm nearby tissues:


bones

cartilage - the stretchy connective tissue that runs between bones

Tendons are the connective Click here tissue that connects bone to muscle

Ligaments The ligaments are the tissues which connects cartilage and bones.

Rheumatoid arthritis may be treated but not treated. The chemicals can cause joints to become unbalanced and distorted. It can eventually destroy the joint.


Although there are numerous theories that explain why the immune system targets the joint, none of them have been confirmed.

Possible risk factors

There are many factors which can increase your risk of developing rheumatoid arthritis including:


Genes. There are indications that arthritis rheumatoid may be a family trait. However, since genes play a tiny part in the condition's development and progression, there's a low likelihood of it being passed to the next generation.

hormones. Rheumatoid arthritis can be more common in women than men, which could be due to effects of the hormone oestrogen, though this has not been proved

Smoking is a major risk factor for rheumatoid arthritis. There is evidence to support this.